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. 2024 Nov 27;14(11):e084904. doi: 10.1136/bmjopen-2024-084904

Table 1. Definitions of TNM for ocular adnexal lymphoma, AJCC Cancer Staging Manual, eighth edition.

Primary tumour (T)
TX Lymphoma extent not specified
T0 No evidence of lymphoma
T1 Lymphoma involving the conjunctiva alone without eyelid or orbital
T2 Lymphoma with orbital involvement with or without conjunctival involvement
T3 Lymphoma with preseptal eyelid involvement with or without orbital involvement and with or without conjunctival involvement
T4 Orbital adnexal lymphoma and extraorbital lymphoma extending beyond the orbit to adjacent structures, such as bone, maxillofacial sinuses and brain.
Regional lymph nodes (N)
 NX Involvement of lymph nodes not assessed
 N0 No evidence of lymph node involvement
 N1 Involvement of lymph node region or regions draining the ocular adnexal structures and superior to the mediastinum (periauricular, parotid, submandibular and cervical nodes)
 N1a Involvement of a single lymph node region superior to the mediastinum
 N1b Metastasis in a single ipsilateral regional lymph node based on lymph node biopsy
 N2 Metastasis in a single ipsilateral regional lymph node, >3 cm in greatest dimension, or in bilateral or contralateral lymph nodes
 N3 Diffuse or disseminated involvement of peripheral and central lymph node regions
Distant metastasis (M)
 M0 No evidence of involvement of other extranodal sites
 M1a Noncontiguous involvement of tissues or organs external to the ocular adnexa (eg, parotid glands, submandibular gland, lung, liver, spleen, kidney, breast)
 M1b Lymphomatous involvement of the bone marrow
 M1c Both M1a and M1b involvement

AJCCAmerican Joint Committee on Cancer