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. 2024 Nov 28;43:312. doi: 10.1186/s13046-024-03218-1

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Genomic organization of TNFR2 and its interaction with TNF-α. A: The TNFRSF1B gene organization on chromosome 1p36.2, consisting of 10 exons ranging from 35 to 2489 bp and 9 introns ranging from 338 to 7500 bp, totals 26 kb. B: Schematic representation of CRD 1–4 of TNFR2 indicating the component of each CRD of the two modules (A1, A2, B1 or B2), CRD 1 (PLAD; A1 and B2), CRD 2 (A1 and B2), CRD 3 (A2 and B1), and CRD 4 (A1 and B2). C: Showing the crystal structure of the 3ALQ (Protein Data Bank ID) of the TNFR2/TNF-α complex, indicating the confirmational interaction between three units of TNFR2 and three units of TNF-α. TNFR2, tumor necrosis factor receptor type 2; tTNF-α, triple tumor necrosis factor; TM, transmembrane; UTR, untranslated region; CRD, cysteine-rich domain; PLAD, pre-ligand assembly domain; kb, kilobases; bp, base pairs; (*), three identical TNFR2 units