Table 1.

Schedule of enrollment, assessments, and interventions.

Item	Study period
	Enrollment	Allocation	Post-allocation	Close-out
Time point (week)	−4–0	0	1–12	12–24
Enrolment
Eligibility screen
Informed consent	×
Inclusion/exclusion	×
Randomization		×
Allocation		×
Intervention
BTG plus standard treatment			×
Standard treatment			×
Assessment
PFS			×	×
Quality of life scores			×	×
Overall survival			×	×
Objective response rate			×	×
Liver-specific PFS			×	×
Disease control rate			×	×
TCM syndrome score			×	×
Piper Fatigue Scale			×	×
KPS			×	×
Adverse events			×	×
Compliance evaluation				×
Acceptability evaluation				×

BTG, Buzhong Tiaogan granule; TCM, Traditional Chinese Medicine; KPS, Karnofsky performance score; PFS, Progression-free survival.