Table 3.
Proinflammatory Adverse Outcomes in Relation to Anatomical and Biomechanical Metrics
| Immune Cells | Biomechanical Metric and Anatomical Variables | Correlationa (r, P Value) | Tertilesb (Mean ± SD, P Value) | Comments |
|---|---|---|---|---|
| Culprit lesion | ||||
| T-cells | Min ESS | −0.381, 0.038 | 1.0 ± 0.96, 0.38 | Inverse correlation indicating that a lower mean min ESS is associated with a higher T-cell count (tertile 3) |
| Plaque upslope | 0.439, 0.015 | 2.9 ± 1.3, 0.17 | Positive correlation indicating that a steeper mean upslope is associated with a higher T-cell count (tertile 3) | |
| CD4+ T cells | Min ESS | −0.342, 0.064 | 1.0 ± 0.96, 0.046 | Inverse correlation indicating that a lower mean min ESS is associated with a higher CD4+ T-cell count (tertile 3) |
| Plaque upslope | 0.455, 0.012 | 2.9 ± 1.3, 0.20 | Positive correlation indicating that a steeper mean upslope is associated with a higher CD4+ T-cell count (tertile 3) | |
| CD8+ T cells | Plaque upslope | 0.483, 0.007 | 2.7 ± 1.4, 0.008 | Positive correlation indicating that a steeper mean upslope is associated with a higher CD8+ T-cell count (tertile 3) |
| NKT cells | Min ESS | −0.366, 0.047 | 0.93 ± 0.127, 0.32 | Inverse correlation indicating that a lower mean min ESS is associated with a higher NKT-cell count (tertile 3) |
| NK cells | Max ESSG axial upslope | 0.194, 0.35 | 7.7 ± 6.7, 0.043 | A higher mean max ESSG axial upslope is associated with a higher NK-cell count (tertile 3) |
| Plaque upslope | 0.388, 0.034 | 2.9 ± 1.3, 0.17 | Positive correlation indicating that a steeper mean upslope is associated with a higher NK-cell count (tertile 3) | |
| Intermediate monocytes | Plaque downslope | 0.490, 0.006 | 2.8 ± 1.7, 0.012 | Positive correlation indicating that a steeper mean downslope is associated with a higher intermediate monocyte cell count (tertile 3) |
| Neutrophils | Plaque downslope | 0.005, 0.98 | 2.7 ± 1.3, 0.046 | A steeper mean downslope is associated with a higher neutrophil cell count (tertiles 2 and 3) |
| Systemic values | ||||
| T cells | Plaque upslope | 0.422, 0.020 | 2.8 ± 1.3, 0.19 | Positive correlation, indicating that a steeper mean upslope is associated with a higher T-cell count (tertile 3) |
| CD4+ T cells | Plaque upslope | 0.456, 0.011 | 2.6 ± 1.1, 0.17 | Positive correlation, indicating that a steeper mean upslope is associated with a higher CD4+ T-cell count (tertile 3) |
| CD8+ T cells | Plaque upslope | 0.443, 0.014 | 2.7 ± 1.4, 0.077 | Positive correlation, indicating that a steeper mean upslope is associated with a higher CD8+ T-cell count (tertile 3) |
| NKT cells | Min ESS | −0.374, 0.042 | 1.0 ± 1.3, 0.26 | Inverse correlation indicating that a lower mean min ESS is associated with a higher NKT-cell count (tertile 3) |
| NK cells | Plaque upslope | 0.378, 0.040 | 2.6 ± 1.2, 0.26 | Positive correlation, indicating that a steeper mean upslope is associated with a higher NK-cell count (tertile 3) |
| Intermediate monocytes | Plaque downslope | 0.524, 0.003 | 2.7 ± 1.57, 0.039 | Positive correlation, indicating that a steeper mean downslope is associated with a higher Intermediate monocyte cell count (tertile 3) |
| Culprit ratio | ||||
| NK cells | Min ESS | −0.148, 0.43 | 0.8 ± 0.78, 0.041 | A lower mean min ESS is associated with a higher NK-cell count (tertile 3) |