Figure 4.

Transcriptomic analysis of progenitor cells derived from different patients

(A) Unsupervised principal component analysis of RNA-seq data progenitor cells derived from complete responsive (CR) and non-responsive (NR) patients (CR, n = 4; NR, n = 3).

(B) Scatterplot of gene expression of NR and CR cell lines. Gray dots represented genes showing no significantly different expression levels.

(C and D) Expression heatmap of gene sets differentially expressed in NR (C) and CR (D) progenitor cells (CR, n = 4; NR, n = 3).

(E and F) GO terms that were significantly enriched in the CR (E) and NR (F) groups (p value <0.05) (CR, n = 4; NR, n = 3).

(G and H) Protein interaction network analysis of the expression of proteins associated with specific GO terms and their interaction relationship in CR (G) and NR (H) groups (CR, n = 4; NR, n = 3).