REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Rabbit polyclonal anti-Iba1	Beyotime	Cat# AF7143, RRID: AB_3662862
Rabbit polyclonal anti-AHR	Beyotime	Cat# AF6165, RRID：AB_3662863
Rabbit polyclonal anti-CYP1A1	Beyotime	Cat# AF6642, RRID: AB_3662864
GAPDH Rabbit mAb	ABclonal Technology	Cat# A19056; RRID:AB_2862549
Horseradish peroxidase labeled Goat anti-Rabbit IgG	Beyotime	Cat# A0208; RRID:AB_2892644
Bacterial and virus strains
Bifidobacterium breve: CCFM1025: Bre1025	Culture Collection of Food Microorganisms (CCFM), Jiangnan University	N/A
B. breve: FHLJDQ3M5: Bre3M5	CCFM, Jiangnan University	N/A
B. bifidum: FNXHL20M2: bif-1	CCFM, Jiangnan University	N/A
B. bifidum: FHuNMY2M1: bif-2	CCFM, Jiangnan University	N/A
B. bifidum: FFJND15M5: bif-3	CCFM, Jiangnan University	N/A
B. bifidum: FHNXY21M6: bif-4	CCFM, Jiangnan University	N/A
B. bifidum: FXJCJ22M1: bif-5	CCFM, Jiangnan University	N/A
B. bifidum: FHeNJZ3M6: bif-6	CCFM, Jiangnan University	N/A
B. bifidum: FXJKS43M4: bif-7	CCFM, Jiangnan University	N/A
B. bifidum: FHeNJZ1M5: bif-8	CCFM, Jiangnan University	N/A
B. bifidum: FGSZY50M8: bif-9	CCFM, Jiangnan University	N/A
B. breve: FGZ3I2M1: bre-1	CCFM, Jiangnan University	N/A
B. breve: FGZ35I2M1: bre-2	CCFM, Jiangnan University	N/A
B. breve: FGZ18I2M1: bre-3	CCFM, Jiangnan University	N/A
B. breve: FGZ9I2M1: bre-4	CCFM, Jiangnan University	N/A
B. breve: FGZ6I2M1: bre-5	CCFM, Jiangnan University	N/A
B. breve: FGZ39I2M1: bre-6	CCFM, Jiangnan University	N/A
B. breve: FGZ23I2M1: bre-7	CCFM, Jiangnan University	N/A
B. breve: FGZ39MM6: bre-8	CCFM, Jiangnan University	N/A
B. breve: FGZ19I2M1: bre-9	CCFM, Jiangnan University	N/A
B. longum subsp. longum: FHBSJZ3M1: lon-1	CCFM, Jiangnan University	N/A
B. longum subsp. longum: FZJZS1M5: lon-2	CCFM, Jiangnan University	N/A
B. longum subsp. longum: FHBSJZ2M3: lon-3	CCFM, Jiangnan University	N/A
B. longum subsp. longum: FHBTS3M2: lon-4	CCFM, Jiangnan University	N/A
B. longum subsp. longum: FHBSJZ6M1: lon-5	CCFM, Jiangnan University	N/A
B. longum subsp. longum: FHBSJZ5M5: lon-6	CCFM, Jiangnan University	N/A
B. longum subsp. longum: FSXBJ11M1: lon-7	CCFM, Jiangnan University	N/A
B. longum subsp. longum: FGDGZ1M1: lon-8	CCFM, Jiangnan University	N/A
B. longum subsp. longum: FHBSJZ1M2: lon-9	CCFM, Jiangnan University	N/A
B. longum subsp. infantis: JSWX3M1: inf-1	CCFM, Jiangnan University	N/A
B. longum subsp. infantis: FGZ19I2M3: inf-2	CCFM, Jiangnan University	N/A
B. longum subsp. infantis: FGZ23I1M7: inf-3	CCFM, Jiangnan University	N/A
B. longum subsp. infantis: FJND2M2: inf-4	CCFM, Jiangnan University	N/A
B. longum subsp. infantis: JSWX25M6: inf-5	CCFM, Jiangnan University	N/A
B. longum subsp. infantis: JSWX6M2: inf-6	CCFM, Jiangnan University	N/A
B. longum subsp. infantis: FGZ23I1M2: inf-7	CCFM, Jiangnan University	N/A
B. longum subsp. infantis: SDZC2M4: inf-8	CCFM, Jiangnan University	N/A
B. longum subsp. infantis: FHeNJZ3M1: inf-9	CCFM, Jiangnan University	N/A
B. adolescentis: FGSYC30M5: ado-1	CCFM, Jiangnan University	N/A
B. adolescentis: FHNFQ38M3: ado-2	CCFM, Jiangnan University	N/A
B. adolescentis: FHNFQ5M4: ado-3	CCFM, Jiangnan University	N/A
B. adolescentis: FHNXY34M5: ado-4	CCFM, Jiangnan University	N/A
B. adolescentis: FJSSZ3M10: ado-5	CCFM, Jiangnan University	N/A
B. adolescentis: FNXHL20M3: ado-6	CCFM, Jiangnan University	N/A
B. adolescentis: FNXHL25M2: ado-7	CCFM, Jiangnan University	N/A
B. adolescentis: FXJCJ25M6: ado-8	CCFM, Jiangnan University	N/A
B. adolescentis: FXJKS34M4: ado-9	CCFM, Jiangnan University	N/A
B. pseudocatenulatum: FGSYC7M5: pse-1	CCFM, Jiangnan University	N/A
B. pseudocatenulatum: FFJNDD5M3: pse-2	CCFM, Jiangnan University	N/A
B. pseudocatenulatum: FFJNDD6M2: pse-3	CCFM, Jiangnan University	N/A
B. pseudocatenulatum: FGSYC4M2: pse-4	CCFM, Jiangnan University	N/A
B. pseudocatenulatum: FGSYC5M4: pse-5	CCFM, Jiangnan University	N/A
B. pseudocatenulatum: FQHXN112M3: pse-6	CCFM, Jiangnan University	N/A
B. pseudocatenulatum: FQHXN3M8: pse-7	CCFM, Jiangnan University	N/A
B. pseudocatenulatum: FQHXN5M4: pse-8	CCFM, Jiangnan University	N/A
B. pseudocatenulatum: FQHXN8M3: pse-9	CCFM, Jiangnan University	N/A
B. dentium: FJSWXJ29M2: den-1	CCFM, Jiangnan University	N/A
B. dentium: FGDLZ75M1: den-2	CCFM, Jiangnan University	N/A
B. dentium: FGSYC1M4: den-3	CCFM, Jiangnan University	N/A
B. dentium: FGZ8I1M1: den-4	CCFM, Jiangnan University	N/A
B. dentium: FHuNMY10M2: den-5	CCFM, Jiangnan University	N/A
B. dentium: FHuNMY7M3: den-6	CCFM, Jiangnan University	N/A
B. dentium: FHuNMY9M2: den-7	CCFM, Jiangnan University	N/A
B. dentium: FNMHLBE6M6: den-8	CCFM, Jiangnan University	N/A
B. dentium: FWX34M7: den-9	CCFM, Jiangnan University	N/A
B. animalis subsp. lactis: FNMGEL1M9: lac-1	CCFM, Jiangnan University	N/A
B. animalis subsp. lactis: AHWH12M3: lac-2	CCFM, Jiangnan University	N/A
B. animalis subsp. lactis: BJHD3M6: lac-3	CCFM, Jiangnan University	N/A
B. animalis subsp. lactis: FNMGHHHT2M2: lac-4	CCFM, Jiangnan University	N/A
B. animalis subsp. lactis: FWX37M4: lac-5	CCFM, Jiangnan University	N/A
B. animalis subsp. lactis: JSYC4M3: lac-6	CCFM, Jiangnan University	N/A
B. animalis subsp. lactis: NMGEL1M5: lac-7	CCFM, Jiangnan University	N/A
B. animalis subsp. lactis: NMGEL2M3: lac-8	CCFM, Jiangnan University	N/A
B. animalis subsp. lactis: NMGHHHT2M1: lac-9	CCFM, Jiangnan University	N/A
B. animalis subsp. animalis: CGMCC1.2268: ani-1	China General Microbiological Culture Collection Center (CGMCC)	CGMCC 1.2268
B. animalis subsp. animalis: CGMCC1.3003: ani-2	CGMCC	CGMCC 1.3003
B. animalis subsp. animalis: GDMCC1.169: ani-3	CGMCC	CGMCC 1.169
Biological samples
Human stool and serum samples in cohort1	Yixing People’s Hospital	ChiCTR2300071025
Human stool samples in cohort2	Jingjiang Chinese Medicine Hospital	ChiCTR2200057145
Chemicals, peptides, and recombinant proteins
Minimum Essential Medium	Meilunbio	Cat# MA0217
Dulbecco’s Modified Eagle Medium	Gibco	Cat# 11965092
Fetal Bovine Serum	Gibco	Cat# A5670701
Fast DNA Spin Kit for Feces	MP Biomedical	Cat# 6570200
FastPure Cell/Tissue Total RNA Isolation Kit V2	Vanzyme	Cat# DC102-01
HiScript III All-in-one RT SuperMix Perfect for qPCR	Vanzyme	Cat# R333-01
ChamQ Universal SYBR qPCR Master Mix	Vanzyme	Cat# Q711-02
DNA gel purification Miniprep kit	Biomiga	Cat# DC3511-01
Mouse Corticosterone (CORT) Enzyme-linked Immunoassay (ELISA) Kit	Senbeijia Biological Technology	Cat# SBJ-M0037
FITC Immunofluorescence Detection Kit	Sangon Biotech	Cat# E670005
SuperSignal West Pico PLUS Chemiluminescent Substrate	ThermoFisher	Cat# 34577
Cell Counting Kit-8 solution	Beyotime	Cat# C0038
RIPA Lysis Buffer	Beyotime	Cat# P0013K
protease phosphatase inhibitors	Beyotime	Cat# P1045
BCA Protein Assay Kit	Beyotime	Cat# P0010
Deposited data
Bacterial genome data	NCBI	# PRJNA1073989
Original western blot images	Mendeley Data	https://doi.org/10.17632/b2xjhzsh94.1
Experimental models: Cell lines
Mouse: NE-4C	ATCC	Cat# CRL-2925
Mouse: BV-2	ATCC	Cat# CRL-2467
Experimental models: Organisms/strains
SPF C57BL/6J mice	Gempharmatech	Cat# N000013
Oligonucleotides
B. breve species-specific primers (BreveT2): F- GAGAAGGCTGAGGCCGT; R- GGGCAGAGAACGAACCTT	This paper	N/A
Bre1025 strain-specific primers (1025T5): F- CCAATAGATTCCACATCGGTTCA; R- CCAGACCAGCCATATAATAATCCA	This paper	N/A
Primers for real-time quantitative-PCR, see Data S4	This paper	N/A
Software and algorithms
Ethovision version 13	Noldus	https://www.noldus.com/ethovision-xt
Compound Discoverer 3.2	Thermo Scientific	Cat# OPTON-31060
SOAPdenovo v2.0.4	BGI Genomics	http://soap.genomics.org.cn/soapdenovo.html#intro2
GapCloser	BGI Genomics	https://sourceforge.net/projects/soapdenovo2/files/GapCloser/bin/r6/GapCloser-bin-v1.12-r6.tgztar
Prodigal v2.6.3	Prodigal Technologies	https://github.com/hyattpd/Prodigal/wiki/introduction
ImageJ	National Institutes of Health	https://imagej.nih.gov/ij/
OrthoMCL v2.0.9	VEuPathDB Project	https://orthomcl.org/orthomcl/app
GraphPad Prism 8	GraphPad Software	https://www.graphpad.com/
Other
Cell chamber culture plate	NEST Biotechnology	Cat# 723001
Cell culture plate	NEST Biotechnology	Cat# 701011