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. 2024 Nov 15;15:1435629. doi: 10.3389/fimmu.2024.1435629

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Copyright © 2024 Xi, Xu, Xu, Wu, Wu, Chen, Liu, Jiang, Yan, Zhang and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Different maturations of TLS. (A) Immature TLS: The germinal center CD21 is negative, and no obvious follicle-like structure is observed. (B) Mature TLS: CD21 positive in the germinal center, with obvious follicle-like structures visible.