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. 2024 Nov 15;15:1473139. doi: 10.3389/fimmu.2024.1473139

Figure 5.

Figure 5

Low PD-1 MFI on total CD8 T-cells, iNKT innate CD8 T-cells are associated with treatment-free remission. (A) Survival without relapse over the first 12 months following TKI cessation in patients with low (blue line) and high (red line) PD-1 MFI on total CD8 T-cells at the moment of TKI cessation. The optimal cut-off value of PD-1 MFI on total CD8 T-cells (151) was calculated using the Youden index. (B) Survival without relapse over the first 12 months following TKI cessation in patients with low (blue line) and high (red line) PD-1 MFI on iNKT cells at the moment of TKI cessation. The optimal cut-off value of PD-1 MFI on iNKT cells (433.5) was calculated using the Youden index. (C) Survival without relapse over the first 12 months following TKI cessation in patients with low (blue line) and high (red line) PD-1 MFI on innate CD8 T-cells at the moment of TKI cessation. The optimal cut-off value of PD-1 MFI on total CD8 T-cells (131.5) was calculated using the Youden index. The number of subjects at risk is shown below the curves. Statistical significance was determined by Log-Rank test.