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Adjusted Principal Coordinates Analysis (aPCoA) plot for repeated measures of vaginal microbiome profiles from the MsFLASH trial, evaluating the impact of vaginal estradiol tablets and/or vaginal moisturizing gel at 0, 4, and 12 weeks. Points are colored by treatment arm: vaginal estradiol tablet plus placebo gel (Arm 1), vaginal moisturizing gel plus placebo tablet (Arm 2), and placebo gel and tablet (Arm 3).
