Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Nov 28;148(1):76. doi: 10.1007/s00401-024-02832-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

PMC Copyright notice

Fig. 6 — Serotonin 5HT1A and 5HT2A receptor histological localization and quantification in the medullary raphe. From IF semiquantitative analysis, there was no difference in a serotonin receptor 5HT1A (p = 0.83) when comparing SUDC-FS and SUDC-noFS, b TPH2 from IF on the same tissue sections with 5HT1A was evaluated in colocalization analyses, c colocalization analysis of 5HT1A and TPH2 showed a low correlation by Mander coefficient in the red channel and a moderate correlation in the green channel, with no difference between SUDC-FS and SUDC-noFS d serotonin receptor 5HT2A was 2.1-fold increased (p = 0.025) when comparing SUDC-FS and SUDC-noFS, e TPH2 from IF on the same tissue sections with 5HT2A was evaluated in colocalization analyses, f colocalization analysis of 5HT2A and TPH2 showed no correlation of the red and green channels. Representative images from IF are shown for 5HT1A (red) g, 5HT2A (red) h, and TPH2 (green) in SUDC-FS and SUDC-noFS. TPH2 indicates the region with serotonergic neurons that was microdissected for proteomic analysis. Scale bar 100 um. Error bars indicate SEM