Fig. 8.

WGCNA of case history in midbrain dorsal raphe, medullary raphe, and the ventrolateral medulla. A correlation analysis of case history variables to proteomics indicated significant modules and associated GO BP annotations in the a midbrain dorsal raphe, b medullary raphe, and c ventrolateral medulla. Modules are clustered by eigenprotein adjacency (relatedness to other modules) on the left. Name of module is indicated by “M-color” and corresponding color block. P values are indicated for those modules with p < 0.05 correlation. Positive correlation is indicated in red and negative correlation in blue. Top module GO BP annotations are noted on the right (FDR < 5% with at least 5 proteins) and detailed in Supplementary Tables 14, 15, 16. Several modules did not have a significant GO BP annotation and are noted as “n.s.” = not significant. FS = febrile seizure. FS duration = FS history duration