FIGURE 1.

Pulse diagram of the PUlse design for Saturation Homogeneity utilizing Universal Pulses (PUSHUP) Chemical exchange saturation transfer (CEST) sequence. The sequence is constituted of two modules. In the saturation modules, $N_{\text{SP}}$ saturation pulses are applied, using three different, alternating ${\mathrm{B}}_1$‐shims. After the last saturation pulse, a crusher gradient dephases transversal magnetization. Afterwards, a CAIPIRINHA accelerated multi‐shot three‐dimensional‐echo planar imaging (3D‐EPI) readout acquires a whole‐brain image. In each of the $N_{\text{shots}}$, universal binomial‐11 GRAPE is used for homogeneous water excitation. The brackets indicate the repetition order. For each of the $N_{\omega }$ off‐center frequencies, all $N_{\text{amp}}$ saturation ${\mathrm{B}}_1$ amplitudes are acquired in direct succession.