Fig. 1.

Hydraulic control of late-stage ovarian follicle development. A Early secondary follicle (100–180 $\mu$m). B Secondary follicle with small pockets of fluids (180–300 $\mu$m). C Pre-ovulatory follicle with fully formed “smiley-faced” antrum (300–400 $\mu$m). D A mouse ovarian tissue slice with DNA (Blue), pan-collagen (yellow) and anti-Müllerian hormone (grey). Scale bar, 300 $\mu$m. E-E’ Ovulation involves the rupture of the follicle wall and the release of oocyte, though the exact mechanism remains poorly understood