Table 2.
Univariate and multivariate analysis of cognitive function vs MAEs in patients with HFrEF
| Cognitive function | ||||
|---|---|---|---|---|
| HR (95% CI) | P Value | |||
| Univariate | ||||
| Per unit change | 0.639 (0.526–0.777) | < 0.001 | ||
| Per SD change | 0.404 (0.272, 0.600) | < 0.001 | ||
| Covariates: age and sex | ||||
| Per unit change | 0.639 (0.523–0.781) | < 0.001 | ||
| Per SD change | 0.404 (0.269–0.605) | < 0.001 | ||
| Coveriates: scar burden and LVEF | ||||
| Per unit change | 0.608 (0.486–0.761) | < 0.001 | ||
| Per SD change | 0.366 (0.232, 0.576) | < 0.001 | ||
| Coveriates: HM and revascularization | ||||
| Per unit change | 0.647 (0.523–0.801) | < 0.001 | ||
| Per SD change | 0.414 (0.269, 0.638) | < 0.001 | ||
| Coveriates: combined cardiac risk factorsa | ||||
| Per unit change | 0.541 (0.385–0.759) | < 0.001 | ||
| Per SD change | 0.288 (0.145, 0.572) | < 0.001 | ||
BNP = brain natriuretic peptide; CI = confidence interval; HM = hibernating myocardium; HR = hazard ratio; LVEF = left ventricular ejection fraction; MAEs = major arrhythmic events; TPD = total perfusion deficit.
aThe cardiac risk factors that were included in this model were each of the cardiovascular risk factors (P < 0.1) that were significantly associated with the development of events based on the univariate analysis (Table S1)—family history, serum albumin, and BNP—that were included as cofactors in a stepwise (forward) conditional manner