Fig. 3.

Indicators of worse DLQI domain and total scores at baseline (n = 267). Variation in HRQL by demographic and clinical variables was compared using Spearman’s rank correlation coefficient for continuous/ordinal variables, Mann–Whitney (two categories), and ANOVA F-test (more than two categories). P values < 0.05 were considered statistically significant. Categories: female/male; Canada/Germany/Japan/USA, Asian/Black or African American/Asian, vIGA 3/4. Higher DLQI scores indicate greater HRQL impairment. ↑, higher; BSA body surface area, DLQI Dermatology Life Quality Index, EASI Eczema Area and Severity Index, HRQL health-related quality of life, NRS Numerical Rating Scale, PRO patient-reported outcome, SCORAD SCORing Atopic Dermatitis, vIGA validated Investigator Global Assessment for Atopic Dermatitis