Table 2.
Biomarkers (except for serum total IgE) and physiological functions when stratified according to SE sensitization.
| All patients (n = 68) | SE (-) (n = 52) | SE (+) (n = 16) | p values | |
|---|---|---|---|---|
| Neutrophils, /µL | 3709 (2921, 4768) | 3746 (2967, 4672) | 3450 (2489, 5871) | 0.83 |
| Eosinophils, /µL | 196 (119, 259) | 196 (116, 252) | 195 (134, 330) | 0.72 |
| Eosinophils ≥ 300 /µL, + | 12 (17.6) | 8 (15.4) | 4 (25) | 0.46 |
| Albumin, g/dL | 4.1 (3.8, 4.3) | 4.1 (3.9, 4.3) | 4.0 (3.6, 4.1) | 0.061 |
| Lactate dehydrogenase, IU/L | 192 (170, 212) | 194 (175, 213) | 184 (158, 205) | 0.27 |
| Hemoglobin A1c, % | 5.8 (5.6, 6.2) | 5.8 (5.6, 6.2) | 6.8 (5.4, 6.4) | 0.70 |
| Brain natriuretic peptide, pg/mL | 34 (18, 67) | 42 (20, 73) | 28 (13, 58) | 0.46 |
| C-reactive protein, mg/L* | 0.12 (0.07, 0.29) | 0.12 (0.07, 0.28) | 0.19 (0.06, 0.52) | 0.54 |
| FeNO, ppb | 23.2 (14.4, 31.2) | 21.7 (13.3, 31.2) | 26.0 (16.2, 32.7) | 0.47 |
| C2, Number of doubling concentrations† | 4 (3, 5) | 4 (3, 6) | 5.5 (4, 8.75) | 0.036 |
| C5, Number of doubling concentrations† | 6 (4, 7) | 5 (4, 7) | 6 (6, 9) | 0.038 |
| Ejection Fraction, % | 64 (61, 70) | 66 (61, 71) | 62 (61, 66) | 0.20 |
| Postbronchodilator FEV1, mL | 1535 (1153, 1905) | 1560 (1285, 1956) | 1280 (943, 1803) | 0.22 |
| Postbronchodilator FEV1 predicted, % | 63.8 (50.4, 76.2) | 64.7 (51.7, 76.2) | 54.5 (43.7, 75.4) | 0.14 |
| Postbronchodilator FEV1/FVC, % | 51.2 (41.0, 60.2) | 53.7 (43.4, 60.5) | 46.5 (32.7, 55.7) | 0.073 |
| Reversibility, % | 3.2 (0, 9.2) | 2.9 (0, 8.5) | 4.2 (− 4.0, 14.3) | > 0.99 |
*n = 66(SE [−]: n = 50/ SE [+]: n = 16), †The number of doubling concentrations of capsaicin ranges from 1 (0.61 µM) to 10(312.5 µM), with a higher number indicating decreased cough sensitivity to inhaled capsaicin. It reflects base 2 logarithmic values of C2 and C5, respectively.