Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Nov 28;14:29627. doi: 10.1038/s41598-024-81304-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 4 — S-Allylmercaptocysteine (SAMC) down-regulates the phosphorylation of various kinases in HC11 cells. (a) The heatmap of phosphorylation of kinases increased by lipopolysaccharide (LPS) (≥ 1.5-fold). LPS and SAMC columns showed the log₂ fold changes of the phosphopeptide abundance in LPS vs. control and SAMC vs. LPS, respectively. (b) Protein-protein interactions among the kinases increased by LPS (≥ 1.5-fold) and decreased by SAMC (≤ 0.75-fold) represented by Markov Cluster Algorithm (MCL) clustering. TLR-related kinases are shown as red spheres, and CDK family is shown as yellow spheres. (c) Protein-protein interactions among the spliceosome-related proteins in Fig. 3f and CDKs family in Fig. 4b represented by MCL clustering. The proteins associated with U2 snRNP, other spliceosome (except U2 snRNP), and CDKs family are shown as green, red, and blue spheres, respectively.