Fig. 1. Approaches for fluorination of alkyl phosphonates.

a Prior approaches rely on multi-step conversion from symmetrical alkyl phosphonates and isolation of intermediates. b This late-stage approach from alkyl phosphonates eliminates the requirement for hash conditions, intricate multi-step transformations and separation. OTf⁻ trifluoromethanesulfonate, TMSBr bromotrimethylsilane, DAST diethylaminosulfur trifluoride, Ar aryl, Me methyl. The blue and pink balls represent different substituents.