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Imp β inhibits RNA binding by HIV-1 Rev. The indicated electrophoretic mobility shift assay was performed essentially as previously described (28) using recombinant HIV-1 Rev protein and a radiolabeled HIV-1 RRE RNA probe. Recombinant Imp β or transportin was added to the RNA binding assays visualized in lanes C to F. In addition, RanGTP (lane D) or RanGDP (lanes E and F) was added as indicated.
