Table 2.
Fifteen hallmark gene sets with at least thee BAG3-interacted proteins.
| Gene Set | Note | BAG3-Interacted Proteins |
|---|---|---|
| Down-regulated in cardiomyopathies | ||
| MYC_TARGETS_V1 | Signal DNA damage-induced apoptosis [20] | HPRT1,PGK1,HNRNPC,EEF1B2,GLO1,C1QBP,PWP1,SF3A1,SERBP1,MRPL9,HDGF,CBX3,PHB2 |
| E2F_TARGETS | Integrate cell cycle progression with DNA repair, replication, and G2/M checkpoints [21] | RFC2,RFC3,PSIP1,CBX5,NUP153,PNN,TMPO,STMN1,NASP,RACGAP1,TP53 |
| G2M_CHECKPOINT | Prevent DNA damaged cells from entering mitosis [22] | NCL,SFPQ,TMPO,STMN1,NASP,TOP1,KIF23,TPX2,RACGAP1 |
| P53_PATHWAY | Promote cell cycle arrest to allow DNA repair or apoptosis [23] | CASP1,DNTTIP2,TP53 |
| APOPTOSIS | Cardiomyocyte apoptosis-interruptus [24] | LMNA,ANXA1,CASP1,CASP4,CASP3,PPT1,BID,BNIP3L,SPTAN1 |
| HYPOXIA | Alter myocardial gene expression and induce cardiomyocyte apoptosis [25] | NAGK,BNIP3L,PRDX5,MIF,PGK1,FOSL2,KLF6 |
| XENOBIOTIC_METABOLISM | Oxidative stress with excessive production of reactive oxygen species (ROS) [26] | HPRT1,PC,PPARD |
| UV_RESPONSE_UP | DNA damage repair [27] | TST,CASP3,PPT1,BID,UROD,ASNS,EIF5,CDC5L |
| UNFOLDED_PROTEIN_RESPONSE | Decrease global protein synthesis, and increase refolding or degradation of misfolded proteins [28] | PARN,BAG3,FUS,EIF4A3,DCP2,KHSRP,ASNS |
| TNFA_SIGNALING_VIA_NFKB | Cardioprotective in hypoxic or ischemic myocardial injury [29] | NFKB2,TRIP10,SGK1,FOSL2,KLF6,PHLDA1,IFIH1 |
| MTORC1_SIGNALING | Regulate cell growth and metabolism [30] and mediate adaptive cardiac hypertrophy [31] | HPRT1,PGK1,PSMC2,ATP6V1D,ASNS |
| ESTROGEN_RESPONSE_LATE | Prevent apoptosis and necrosis of cardiac and endothelial cells [32] | TST,HPRT1,DHRS2,SGK1 |
| PI3K_AKT_MTOR_SIGNALING | Lead to cell proliferation [33] and inhibit cardiomyocyte apoptosis [34] | CFL1,ECSIT,PIKFYVE,MAP3K7 |
| IL2_STAT5_SIGNALING | Modulate CD4+ Th cell differentiation [35] and upregulate the expression of c-Myc, BCL-2, and BCL-x [36] | CASP3,KLF6,PHLDA1 |
| Up-regulated in cardiomyopathies | ||
| INTERFERON_ALPHA_RESPONSE | Interferon inhibits cardiac cell function in vitro [37] and interferon treatment has been shown of cardiotoxicity [38]. | CASP1,IRF9,TRIM21,IFI44,SP110,IFIH1 |