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. 2024 Nov 20;29(2):67. doi: 10.3892/ol.2024.14813

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Copyright: © 2024 Huang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — AZD2281 promotes apoptosis and inhibits colony formation in COV362 cells. (A) IC₅₀ of AZD2281 in OVCAR5 and COV362 cells were assessed. (B) Cell apoptosis at different time points (ctrl, 12, 24 and 48 h) after treatment with 400 nM AZD2281 in OVCAR5 and COV362 cells. ***P<0.001; ****P<0.0001. (C) Cell cycle progression at different time points (0, 12, 24 and 48 h) after treatment with 400 nM AZD2281 and in different cell cycle phases (G1, S, and G2) in OVCAR5 and COV362 cells. ***P<0.001 vs. Ctrl (G1); ^###P<0.001 vs. Ctrl (G2). (D) Colony formation at different time points (ctrl, 12, 24 and 48 h) after treatment with 400 nM AZD2281 in OVCAR5 and COV362 cells. ****P<0.0001. IC₅₀, half-maximal inhibitory concentration; Ctrl, control.