Fig. 2.

Mean hazard ratios and 95 % confidence intervals of 100 bootstrap samples on which the Cox regression model predicting LRR in the non-NST cohort is developed. ∗ As age is modeled using restricted cubic splines, the interpretation of the coefficients is not straightforward, as the effect of age on risk of LRR is a function of multiple regression coefficients. Abbreviations: LRR = locoregional recurrence, NST = neoadjuvant systemic treatment, HR = hazard ratio, LCL = lower confidence limit, UCL = upper confidence limit, pT = pathological tumour classification, pN = pathological nodal classification, HER2 = human epidermal growth factor 2, RT = radiation therapy.