Fig. 4: Effect of lamotrigine (Lamo) administered 45 minutes before the test combined with 8-OH-DPAT administered 30 minutes before the test on immobility time in the FST. The results, in terms of percentage relative to the control group, are expressed as mean and SEM (n = 10 in each group). The asterisks indicate significant differences from the appropriate lamotrigine control group, determined by 2-way ANOVA followed by a Sidak test: ***p ≤ 0.001.