Table 2.
Promoter methylation of HR genes in cases with HRD
| POG ID | Tumor type | Analysis cohort | Gene | Fraction of methylated sites | LOH status | HRDetect |
|---|---|---|---|---|---|---|
| POG425 | BRCA | breast and ovarian | BRCA1 | 0.922 | LOH | 0.998 |
| POG507 | BRCA | breast and ovarian | BRCA1 | 0.951 | LOH | 0.999 |
| POG804 | BRCA | breast and ovarian | BRCA1 | 0.961 | LOH | 0.999 |
| POG356 | BRCA | breast and ovarian | RAD51C | 0.739 | LOH | 0.992 |
| POG846 | OV | breast and ovarian | RAD51C | 0.554 | LOH | 0.998 |
| POG894 | OV | breast and ovarian | RAD51C | 0.587 | LOH | 0.999 |
| POG277 | LUNG | other | BRCA1 | 0.804 | HET | 0.007 |
| POG1041 | MISC | other | BRCA1 | 0.765 | LOH | 0.319 |
| POG650 | HNSC | other | BRCA1 | 0.657 | LOH | 0.635 |
| POG785 | HNSC | other | RAD51C | 0.576 | HET | 0.032 |
| POG266 | CHOL | other | RAD51C | 0.554 | HET | 0.103 |
| POG044 | CNS-PNS | other | RAD51C | 0.552 | HET | 0.001 |