Figure 2.

The gene network of the 84 perturbed genes

(A) Estimate of the directed network that describes how the 84 perturbed genes interact. The radius of each point is proportional to the degree of that gene. Arrows are used to indicate directionality of the edges, such that an arrow pointing into a gene indicates that it is being regulated by another gene. For emphasis, the opacity of the edges from or to inborn error of immunity transcription factors is increased, and all other edges are displayed with greater transparency. Positive values in the color scale indicate that the parent gene is a positive regulator of the child gene.

(B) A sub-network centered around STAT1.

(C) A scatterplot of the indegree and outdegree of each of the 84 genes.

(D) Association analyses between gene properties and their indegree, outdegree, and total degree.