Table 1.

Summary of occupancies and maximum CBV changes following serotonergic drug injection.

	Psilocybin			Lisuride	25CN-NBOH
Dose	30 µg/kg	60 µg/kg	90 µg/kg	5 µg/kg	30 µg/kg
DMN
Occupancy	3.86 ± 4.75	19.30 ± 5.61	18.70 ± 12.31	25.77 ± 6.85	4.46 ± 0.75
CBVγ1	−3.12 ± 0.89	−6.00 ± 2.00	−1.90 ± 1.73	−6.80 ± 2.25	N/A
CBVγ2	+3.65 ± 1.25	+5.27 ± 1.75	+7.01 ± 1.38	+10.73 ± 6.10	12.78 ± 6.72
Cortices
Occupancy	11.00 ± 9.39	31.83 ± 5.68	28.88 ± 12.89	31.37 ± 11.19	7.11 ± 3.50
CBVγ1	−3.36 ± 0.84	−5.94 ± 2.19	−3.08 ± 1.62	−5.56 ± 2.05	N/A
CBVγ2	+3.32 ± 1.49	+4.11 ± 1.94	+5.09 ± 2.55	+10.26 ± 9.67	13.44 ± 4.00

DMN is a summed average of ACC, PCC, and Precuneus. Cortices is a summed average of Motor, Sensory, and Occipital cortices. All data are averages and standard deviations across datapoints for included ROI across NHP used for the defined networks, rounded to the nearest hundredth decimal place, represented as percentages. Occupancies below 0%, if observed, were excluded. After thresholding in the Cortices, total datapoints for Psilocybin 30, 90 µg/kg and Lisuride are N = 6 for Occupancy and CBV; total datapoints for psilocybin 60 µg/kg for Occupancy are N = 6, for CBV N = 9; total datapoints for 25CN-NBOH are N = 9 for CBV, N = 6 for Occupancy After thresholding in the DMN, all total datapoints were the same as Cortices, with the exception of 25CN-NBOH N = 3 for Occupancy. Please refer to the method section for the definition of CBV_γ1 and CBV_γ2.