Table 2.

Examples of available drug compounds with proposed mechanistic impact on MED13L (direct and indirect).

Compound	Data source	Target	Impact on MED13L
Clofibrate70,71/Bezafibrate 72	CTD/UAB	Drp1	Effect MED13L expression/Improves mitochondrial fission and function
Lithium 73	UAB	Drp1	Inhibition of mitochondrial fission through downregulation of Drp1
Verapamil 74	UAB	FRZB	Suppresses Wnt/β-catenin signaling, valuable in missense variants that upregulate MED13L
Nutraceuticals/Supplements
PSE 75	UAB	LRP5	The oral administration of PSE, a dietary cholesterol-lowering agent, had an effect on the expression levels of the Wnt signaling receptor
EPA and DHA 76	UAB	MFN2	Recovery of mitochondrial function by increasing Mfn2 expression
Ginkgo biloba 77	UAB	Drp1	Reduced mitochondrial fission

The table outlines specific drugs or alternative compounds that interact with MED13L directly by upregulating or downregulating expression or through indirect mechanisms such as preservation of mitochondrial dysfunction, interaction with the Wnt pathway, or other distinct known downstream paths as outlined. CTD, comparative toxicogenomic dataset; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; PSE, plant sterol esters; UAB, University of Alabama-Birmingham.