Table 1.

Heterogeneity and pleiotropy test

Exposure	Heterogeneity test						Pleiotropy test
	MR-Egger			Inverse variance weighted			MR-Egger
	Q	Q_df	Q_pval	Q	Q_df	Q_pval	Egger intercept	se	pval
Coprococcus1	2.376	12	0.999	2.536	13	0.999	8.64E-05	0.0002	0.696
Slackia	4.513	7	0.719	5.182	8	0.738	-0.0004	0.0005	0.441
Butyricicoccus	3.543	7	0.831	4.312	8	0.828	-0.0002	0.0002	0.409
Eubacterium coprostanoligenes group	10.539	13	0.649	11.352	14	0.658	0.0003	0.0004	0.384
Bacteroides	9.633	9	0.381	10.071	10	0.434	-0.0004	0.0006	0.538

Q: Heterogeneity static Q; df: Degree of freedom; se: Standard error