Fig. 2.

Time-varying adjusted hazard ratio (HR) of transplant failure (death or end-stage kidney disease, ESKD) of patients with cTMA compared to dnTMA. The hazard ratio is highest shortly after transplantation, and then decreases with time. The model is adjusted for age, gender, ethnicity, donor type, induction with lymphodepleting agents, DGF, eculizumab use (any time), and biopsy diagnosis (time-varying cumulative sum). The line represents the hazard ratio estimates, the blue shaded area represents the 95 percent confidence interval; cTMA, complement-mediated thrombotic microangiopathy