Table 1.
Baseline Patients Characteristic
| dnTMA | cTMA | p-value | |
|---|---|---|---|
| N | 112 (83.6%) | 22 (16.4%) | |
| † Mean (SD) Age at TMA diagnosis, years | 46.5 ± 16.0 | 28.9 ± 16.3 | < 0.001 |
| Mean (SD) Age at transplant, years | 46.1 ± 14.8 | 38.5 ± 10.6 | 0.022 |
| Ethnicity | |||
| White | 66 (58.9%) | 17 (77.3%) | 0.287 |
| Black | 42 (37.5%) | 5 (22.7%) | |
| Other | 4 (3.6%) | 0 (0.0%) | |
| Gender, Female | 56 (50.0%) | 15 (68.2%) | 0.161 |
| Donor type | |||
| Deceased donor | 69 (61.6%) | 9 (40.9%) | 0.185 |
| Living unrelated | 20 (17.9%) | 6 (27.3%) | |
| Living related | 23 (20.5%) | 7 (31.8%) | |
| Donor's age, years | 43.5 ± 14.9 | 37.0 ± 13.7 | 0.038 |
| Donor's terminal Creatinine, mg/dL | 1.1 (0.4–4.0) | 1.4 (0.5–6.5) | 0.540 |
| Highly sensitized | 47 (67.1%) | 15 (75.0%) | 0.592 |
| ‡ HLAi or ABOi transplant (required desensitization) | 46 (51.1%) | 6 (30.0%) | 0.136 |
| § Pre-transplant DSA | 50 (66.7%) | 8 (40.0%) | 0.04 |
| Re-transplantation | 63 (56.2%) | 13 (59.1%) | 1 |
| Warm ischemic time, minutes | 47.2 ± 24.8 | 42.5 ± 11.8 | 0.641 |
| Cold ischemic time, hours | 19.7 ± 17.2 | 10.3 ± 10.8 | 0.023 |
| Delayed graft function | 45 (40.9%) | 4 (18.2%) | 0.054 |
| Reason for previous graft loss | |||
| TMA | 4 (5.3%) | 15 (93.8%) | < 0.001 |
| ¶ Acute ABMR | 9 (11.8%) | 0 (0.0%) | |
| Chronic ABMR | 30 (39.5%) | 0 (0.0%) | |
| BK nephropathy | 3 (3.9%) | 0 (0.0%) | |
†SD standard deviation, TMA thrombotic microangiopathy
‡HLAi Human leukocyte antigens incompatible, ABOi ABO-incompatible
§DSA donor specific antibody
¶ABMR antibody mediated rejection