Table 2.
Clinical and pathological findings at the time of post-transplant TMA diagnosis
| dnTMA (N = 112) | cTMA (N = 22) | p-value | |
|---|---|---|---|
| Number of graft biopsies | 4.0 (1.0–12.0) | 3.5 (0.0–10.0) | 0.134 |
| Time from first to last biopsy, months | 18.8 (0.0–296.2) | 45.2 (0.6–1290.0) | 0.197 |
| † Median (IQR) of SCr at time of diagnostic biopsy, mg/dL | 3.6 (0.4–24.0) | 2.0 (0.7–15.6) | 0.043 |
| ‡ Mean (SD) of Hg at time of diagnostic biopsy, g/dL | 9.4 ± 2.0 | 9.6 ± 1.5 | 0.449 |
| Median (IQR) of platelets count at time of diagnostic biopsy, × 1000/dL | 167 (21.0–459) | 176 (47.0–396) | 0.855 |
| Median (IQR) of LDH at time of diagnostic biopsy, UI/L [Ref. 100–200] | 312 (91–1547) | 286 (200–1183) | 0.753 |
| Median (IQR) of last SCr, mg/dL | 3.1 (0.3–17.8) | 2.3 (0.4–5.0) | 0.025 |
| § Mean (SD) of last eGFR, mL/min/1.73 m2 | 23.5 ± 22.1 | 42.2 ± 27.3 | 0.003 |
| Mean (SD) of last Hemoglobin, g/dL | 10.6 ± 2.2 | 9.5 ± 2.7 | 0.212 |
| Rejection in the diagnostic biopsy | 49 (43.8%) | 2 (10.0%) | 0.005 |
| ¶ TCMR in diagnostic biopsy | 26 (23.2%) | 0 (0.0%) | 0.007 |
| # CNI toxicity in diagnostic biopsy | 34 (30.4%) | 1 (5.0%) | 0.025 |
| Rejection, at least in one biopsy | 90 (80.4%) | 11 (50.0%) | 0.005 |
| ††ABMR, at least in one biopsy | 29 (25.9%) | 1 (4.5%) | 0.027 |
| ‡‡ CTG, at least in one biopsy | 11 (9.8%) | 3 (13.6%) | 0.701 |
| CNI toxicity, at least in one biopsy | 80 (71.4%) | 5 (22.7%) | < 0.001 |
†SCr serum creatinine
‡Hg Hemoglobin
§eGFR estimated glomerular filtration rate
¶TCMR T cell mediated rejection, antibody-mediated rejection
#CNI calcineurin inhibitor
††ABMR antibody mediated rejection
‡‡CTG chronic transplant glomerulopathy