Table 1.
Demographics
| Demographics | UCH SPSD cohort (n = 59) | Total UCH population (n = 2,801,674) |
| Age,a y, mean (SD) | 49.7 (12.9) | 47.5 (18.7) |
| Sex assigned at birth, n (%) | ||
| Female | 35 (59.3) | 1,519,928 (54.3) |
| Male | 24 (40.7) | 1,281,064 (45.7) |
| Unknown | 0 (0) | 682 (0.02) |
| Race, n (%) | ||
| White | 48 (81.4) | 2,063,672 (75.6) |
| Black | 5 (8.5) | 162,273 (6.0) |
| American Indian or Alaskan Native | 1 (1.2) | 15,732 (0.6) |
| More than 1 race | — | 21,121 (0.8) |
| Other | 4 (6.8) | 365,518 (13.0) |
| Unknown | — | 173,358 (6.2) |
| Ethnicity, n (%) | ||
| Hispanic, Latino/a, or Spanish origin | 5 (8.5) | 384,125 (13.7) |
| Non-Hispanic, Latino/a, or Spanish origin | 54 (91.5) | 2,213,032 (79.0) |
| Unknown | — | 204,517 (7.3) |
| SPSD phenotype, n (%) | ||
| Classic SPS | 39 (66.1) | — |
| Partial or stiff limb | 1 (1.7) | — |
| SPS plus | 16 (27.1) | — |
| PERM | 3 (5.1) | — |
| Comorbidities, n (%) | ||
| Type 1 diabetes mellitus or latent autoimmune diabetes of adults or LADA | 9 (15.3) | — |
| Thyroid disease | 26 (44.1) | — |
| Vitamin B12 deficiency | 26 (44.1) | — |
| Vitiligo | 8 (13.6) | — |
| Epilepsy | 4 (6.8) | — |
| Neuropathy | 37 (62.7) | — |
| Rheumatoid arthritis | 3 (5.1) | — |
| Previous spinal surgery | 8 (13.6) | — |
| Anxiety | 39 (67.2) | — |
| Depression | 27 (46.6) | — |
| Chronic opioid useb | 15 (25.4) | — |
| Self-reported chronic alcohol usec | 3 (5.1) | — |
Abbreviations: LADA = latent autoimmune diabetes of adults; PERM = progressive encephalomyelitis with rigidity and myoclonus; SPS = stiff person syndrome; SPSD = stiff person spectrum disorder; UCH = University of Colorado Health.
a
Age was calculated at either SPS diagnosis or at the midpoint of their exposure for patients without an SPS diagnosis.
b
Defined as >3 months of continuous use.
c
Defined as >7 standard drinks in a consecutive 7-day period.