Fig. 5. Impact of PM_2.5 on immune cell type proportion depending on pregnancy status.

(A) Single-cell UMAP visualizations of histone acetylation and methylation, colored by cell type identity. (B) Frequency of immune cell subtypes in low and high PM_2.5 exposure groups of pregnant and nonpregnant women. The y axis represents the frequency of cells as a percentage of a total number of 11 immune cells population, and the x axis shows the groups categorized by pregnant and PM_2.5 exposure states: NPL (nonpregnant low), NPH (nonpregnant high), PL (pregnant low), and PH (pregnant high). The box plot is colored by pregnant status (red, pregnant; blue, nonpregnant). Lines present the changes in cell proportions between low and high exposures within each pregnant status. P values (P) of the interaction term between pregnant status and PM_2.5 exposure are noted above graph.