Table 2. HPTM modules and model preservation.
Modules within networks are groups of HPTMs that are tightly connected or coexpressed. To check whether the network topology of each module is preserved between groups, we run a permutation test. We considered a module to be preserved between two groups if a permutation test P value <0.05. Descriptions for the abbreviations of histone modifications can be found in table S1.
| Epigenetic marker | Nonpregnant low versus high | Pregnant low versus high | ||
|---|---|---|---|---|
| (P value) | (P value) | |||
| Acetylation | Module 1 | H2BK120ub, CrotonylK, H3R2cit | 0.236 | 0.292 |
| Module 2 | H4K16ac, H3K23ac, H3K56ac, AcetylK, gammaH2AX | 0.433 | 0.315 | |
| Module 3 | H3K18ac, H2BK5ac, H3S10ph, H4K5ac, H3K9ac | 0.049 | 0.039 | |
| Methylation | Module 1 | H3K4me3, H2A.Z, Rme1, H3K4me2, H3K9me1, CENPA | 0.708 | 0.716 |
| Module 2 | H3K36me1, H3K36me2 H4K20me2, H4K20me3 | 0.282 | 0.030 | |
| Module 3 | H3K27me1, Rme2sym, Rme2asy, H3K27me2 | 0.035 | 0.026 |