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The summary in the effects of Pb on TNF-R1-RIPK1/RIPK3 pathway
| Protein | HT-22 cell | primary mouse hippocampal neurons | Mice |
|---|---|---|---|
| TNF-R1 | ↑ | - | ↑ |
| RIPK1 | ↑ | ↑ | ↑ |
| P-RIPK1 | ↑ | ↑ | ↑ |
| RIPK3 | ↑ | - | ↑ |
| MLKL | ↑ | ↑ | ↑ |
| p-MLKL | ↑ | ↑ | ↑ |
| PARP | ↑ | ↑ | ↑ |
| c-PARP | ↑ | ↑ | ↑ |
| caspase-8 | / | / | ↓ |
Note: (−) No change, (/) Not acquire.
P<0.05 and
P<0.01: compared to the Control group.
