Figure 1.

Comparison over time between planned and performed oncological management following maximal safe function-based resection of grade 3 gliomas, IDH-mutant. (A) Evolution over time of the watch-and-wait approach versus early adjuvant oncological treatment postoperatively. (B) Evolution over time between the planned and the performed oncological management postoperatively. Before 2017, the early adjuvant treatment was decided in multidisciplinary meetings and applied in all cases, except in rare cases of patient refusal. Since 2017, a watch-and-wait approach has increasingly been proposed by the referring neurosurgeons and accepted by the patients despite the decision of early adjuvant treatment in multidisciplinary meetings. Since 2019, the watch-and-wait approach has increasingly proposed adequacy between the postoperative management decided in multidisciplinary meetings and accepted by the patients. (C) Illustrative cases of patients who received a watch-and-wait approach following maximal-safe function-based awake resection. Left panel: preoperative, 24-month postoperative, and 152-month postoperative MRI of patient n°1 of the surgery group (Supplementary Table 2). Middle panel: preoperative, 24-month postoperative, and 62-month postoperative MRI of patient n°6 of the surgery group (Supplementary Table 2). Right panel: preoperative, 24-month postoperative, and 82-month postoperative MRI of patient n°3 of the surgery group (Supplementary Table 2).