Table 3.

Uni- and multivariate analyses of risk factors for OSSN recurrence (prognostic factors)

	Univariate			Multivariate n = 70
Variable	HR	95%CI	P value	HR	95%CI	P value
Age - year	1.02	[0.98, 1.06]	0.297	1.05	[1.00, 1.09]	0.028
Sex - Male	0.81	[0.32, 2.01]	0.646	0.69	[0.26, 1.81]	0.449
Pathological diagnosis
Dysplasia	Ref.			Ref.
CIN	2.02	[0.25, 16.45]	0.511	2.82	[0.37, 21.36]	0.316
SCC	2.46	[0.32, 19.07]	0.389	2.85	[0.41, 19.81]	0.289
Lesion location
Corneal limbus (1–2 quadrant)	Ref.			Ref.
Corneal limbus (3–4 quadrant)	2.79	[1.04, 7.50]	0.043	1.92	[0.60, 6.13]	0.271
Palpebral conjunctiva	0.55	[0.07, 4.35]	0.570	1.35	[0.19, 9.63]	0.766
In bulbar & palpebral conjunctiva	4.08	[0.88, 18.95]	0.073	7.17	[1.10, 46.73]	0.039
Size - mm	1.19	[1.05, 1.34]	0.005	1.20	[1.01, 1.41]	0.037
HPV16 - positive	1.26	[0.29, 5.54]	0.757

OSSN, ocular surface squamous neoplasia; HR, hazard ratio; CI, confidence interval; CIN, carcinoma in situ; SCC, squamous cell carcinoma