Table 4.

Uni- and multivariate analyses of risk factors for OSSN recurrence (treatment)

	Univariate			Multivariate n = 70
Variable	HR	95%CI	P value	HR	95%CI	P value
Age - year	1.02	[0.98, 1.06]	0.297	1.03	[0.98, 1.09]	0.251
Sex - Male	0.81	[0.32, 2.01]	0.646	0.79	[0.29, 2.13]	0.646
Pathological diagnosis
Dysplasia	Ref.			Ref.
CIN	2.02	[0.25, 16.45]	0.511	2.63	[0.35, 19.88]	0.349
SCC	2.46	[0.32, 19.07]	0.389	3.42	[0.45, 26.18]	0.237
Lesion location
Corneal limbus (1–2 quadrant)	Ref.			Ref.
Corneal limbus (3–4 quadrant)	2.79	[1.04, 7.50]	0.043	1.15	[0.30, 4.36]	0.836
Palpebral conjunctiva	0.55	[0.07, 4.35]	0.570	1.55	[0.21, 11.77]	0.670
In bulbar & palpebral conjunctiva	4.08	[0.88, 18.95]	0.073	17.22	[1.42, 209.59]	0.026
Size - mm	1.19	[1.05, 1.34]	0.005	1.10	[0.88, 1.39]	0.403
Operation
None	Ref.			Ref.
LT/KEP	3.74	[1.03, 13.59]	0.045	1.45	[0.30, 7.04]	0.645
AMT	1.17	[0.19, 6.99]	0.866	0.92	[0.12, 6.82]	0.939
Others (COMET, CT, ET + AMT)	2.84	[0.63, 12.74]	0.172	0.98	[0.11, 8.74]	0.985
MMC	0.77	[0.25, 2.32]	0.639	1.16	[0.29, 4.59]	0.834
5-FU	0.10	[0.02, 0.45]	0.003	0.12	[0.02, 0.60]	0.010
IFN	1.50	[0.34, 6.52]	0.591	1.27	[0.23, 6.95]	0.784

OSSN, ocular surface squamous neoplasia; HR, hazard ratio; CI, confidence interval; None, only excision of the tumor; LT, limbal transplantation; KEP, keratoepithelioplasty; AMT, amniotic membrane transplantation; COMET, cultivated oral mucosal epithelial transplantation; CT, auto-conjunctival transplantation; ET, epithelial transplantation; MMC, mitomycin-C; 5-FU, 5-fluorouracil; IFN, interferon-α-2b