Table 3.
The general importance of features in the brain radiomics model and the comprehensive brain-psychological-clinical model and the differences of these features between CD patients and HCs
| Features | Mean SHAP value | Mean or median of features | ||
|---|---|---|---|---|
| HCs | CD patients | p-value | ||
| Neural radiomics model | ||||
| Left-Hippocampus R2Star p10 | 1.81 | 12.28 ± 1.29 | 11.26 ± 1.93 | 0.001 |
| Left-Putamen fMRI ReHo p10 | 1.41 | −1.00 ± 0.12 | −0.91 ± 0.16 | < 0.001 |
| Ctx-Lh-Caudal-Anterior-Cingulate DKI KFA std | 1.29 | 0.11 ± 0.01 | 0.13 ± 0.02 | < 0.001 |
| Ctx-Lh-Middle-Temporal CBF p90 | 1.13 | 131.01 [113.96, 142.40] | 150.66 [127.77, 757.86] | < 0.001 |
| Ctx-Rh-Postcentral fMRI ReHo p90 | 1.07 | 1.54 ± 0.25 | 1.31 ± 0.30 | < 0.001 |
| Ctx-Lh-Superior-Temporal vol | 0.95 | 0.02 ± 0.001 | 0.01 ± 0.001 | 0.002 |
| Brain-Stem fMRI ALFF p90 | 0.93 | 0.15 [0.02, 0.55] | 0.65 [0.26, 1.07] | < 0.001 |
| Left-Thalamus-Proper CBF std | 0.78 | 14.32 [13.06, 16.79] | 18.88 [15.73, 328.67] | < 0.001 |
| Ctx-Lh-Cuneus fMRI ReHo std | 0.66 | 0.78 ± 0.15 | 0.85 ± 0.17 | 0.02 |
| Ctx-Rh-Superior-Frontal DKI GA std | 0.49 | 0.17 ± 0.08 | 0.25 ± 0.17 | 0.003 |
| Ctx-Rh-Precentral fMRI ALFF p10 | 0.47 | 0.36 [0.03, 0.55] | 0.04 [−0.22, 0.27] | < 0.001 |
| Ctx-Lh-Middle-Temporal vol | 0.38 | 0.012 ± 0.001 | 0.011 ± 0.001 | < 0.001 |
| Ctx-Rh-Precentral fMRI ReHo mean | 0.21 | −0.49 ± 0.07 | −0.55 ± 0.07 | < 0.001 |
| Clinical-psychological-neural model | ||||
| Rad-score | 3.33 | 0.03 [0.002, 0.11] | 0.10 [0.94, 0.10] | < 0.001 |
| Alcohol | 0.75 | 0 [0, 0] | 0 [0, 1] | < 0.001 |
| Education | 0.55 | 6.00 [5.00, 6.00] | 4.00 [4.00, 5.00] | < 0.001 |
| S-score | 0.40 | 29.35 ± 5.90 | 41.66 ± 10.26 | < 0.001 |
| BMI | 0.34 | 22.68 ± 2.24 | 20.13 ± 3.34 | < 0.001 |
| T-score | 0.27 | 31.37 ± 5.95 | 43.06 ± 9.95 | < 0.001 |
| PSS | 0.25 | 29.24 ± 6.17 | 37.20 ± 7.91 | < 0.001 |
| BDI | 0.25 | 3.70 ± 3.60 | 11.39 ± 9.46 | < 0.001 |
Data are presented as mean ± standard deviation for data that follow a normal distribution, or as median (interquartile range) for data that do not follow a normal distribution
p10 10th percentile, fMRI functional MRI; ctx cortex, ReHo regional homogeneity, DKI diffusion kurtosis imaging, KFA kurtosis fractional anisotropy, STD standard deviation, CBF cerebral blood flow, p90 90th percentile, vol volume, ALFF amplitude of low-frequency fluctuations, DKI diffusion kurtosis imaging, GA geodesic anisotropy, Rad-score radiomics score, S-score state score of state-trait anxiety inventory, T-score trait score of state-trait anxiety inventory, BMI body mass index, PSS perceived stress scale, BDI Beck depression inventory, CD Crohn’s disease, HCs healthy controls