TABLE 1.

Relative drug resistance conferred by MDR1 or its mutants

MDR1 or mutant	Mean relative drug resistancea ± SE to:
	Bisan-trene	Colchi-cine	Dauno-mycin	Vincris-tine
neo	1	1	1	1
MDR1(V185)	12.2 ± 1.2	13.5 ± 0.1	4.3 ± 0.3	3.8 ± 0.8
MDR1-MDR2(307–392)	2.4 ± 0.5	1.2 ± 0.1	1.2 ± 0.2	1.4 ± 0.3
MDR1-MDR2(307–392)QVL	7.2 ± 1.3	8.4 ± 1.2	2.3 ± 0.3	2.2 ± 0.1
MDR1-MDR2(307–392)EKKSK	1.9 ± 0.2	2.1 ± 0.3	1.2 ± 0.4	1.1 ± 0.1

^aThe number represents the ratio of IC₅₀ [MDR]/IC₅₀ [neo].