Table 1.
Overview of innate lymphocytes
| Immune cell subsets | Nomenclature | Surface markers | Transcription factors | Development | Tissue locations | Cytokine and effector profile |
|---|---|---|---|---|---|---|
| ILC | cNK, trNK | NK1.1, NKp46, CD49b | EOMES, T-bet | Bone marrow | Lymphoid and non-lymphoid tissues | IFNγ, TNFα, cytotoxic molecules |
| ILC1 | NK1.1, NKp46, CD49a, CD200R1 | HOBIT, T-bet | Bone marrow | Non-lymphoid tissues | IFNγ, TNFα | |
| ILC2 | ICOS, IL17Rβ | GATA-3, RORα | Bone marrow | Most abundant in the lung | IL-4, IL-5, IL-9, IL-13, AREG | |
| ILC3 | NKp46, AhR | RORγt, T-bet, | Bone marrow | Most abundant in the gut | IL-17, IL-22, GM-CSF | |
| LTi | CCR6 | RORγt | Bone marrow | Lymphoid tissues | IL-17, IL-22 | |
| γδ T cells | γδ17, γδIFN | CD27, CD45RB, CD44 | RORγt, T-bet, | Thymus | Most abundant in the intestine, skin, brain, adipose tissue | IL-17, IFNγ |
| iNKT cells | NKT1 | CD24lo, NK1.1hi, CD27hi, CXCR3+ | T-bet | Thymus | Most abundant in liver, spleen, adipose tissue | IFNγ, IL-2, IL-4, IL-10, IL-17, TNF |
| NKT2 | CD24lo, CD27hi, CD4+ | GATA-3, PLZF | ||||
| NKT17 | CD24lo, CCR6+, CD103hi, SDC-1+ | RORγt | ||||
| NKT10 | PD-1, ICOS, Nrp1 | E4BP4 |