Gut microbial characteristics of the cohort. (a) SCAD and MI
patients were characterized by lower microbial richness in Shannon and Simpson
indexes based on genera level compared to healthy controls. (b) Differentially
changed bacteria feature in SCAD, MI and Control according to distance-based
redundancy analysis based on the Bray-Curtis distance. perMANOVA test, 9999
permutations, p values were annotated. (c) Species significantly changed
in the CAD compared to Control group (p value 0.01 and fold change
1.2 or 0.83). (d) Spearman correlation between significantly altered
species and disease severity indicator. Wilcoxon rank sum test; **, p
0.01; ***, p
0.001. Con, control subjects; SCAD, stable coronary
artery disease; MI, myocardial Infarction; CAD, coronary artery disease; HC, healthy control; PC, principal component.