Figure 4.

Adaptive protocol example: supplementation with bupropion for early non-responders to NRT or varenicline

This figure illustrates an adaptive protocol which improved cessation outcomes in an RCT comparing randomization to an adaptive vs. non-adaptive protocol. In the adaptive protocol arm, participants chose between nicotine patch or varenicline, early response was monitored, and for early non-responders (less than 50% reduction in smoking), bupropion was added to the initially preferred product.⁷⁰ Study participants who were randomized to a non-adaptive protocol continued on their initially preferred monotherapy regardless of early responder status (not shown).