Table 1.
Study | Study design | Included participants (n) | Sex |
Age, years (mean ± SD) [range] |
GMFCS level (n) | Distribution and motor type of CP (n) |
---|---|---|---|---|---|---|
Balemans et al.23,‡ | Cross-sectional case-control analysis (data from mixed designs) | TD: 31 | Boys: 14 Girls: 17 |
10.0 ± 1.6 | na | na |
CP: 70 | Boys: 35 Girls: 35 |
9.9 ± 1.6 10.3 ± 2.4 9.5 ± 2.0 |
GMFCS I: 36 GMFCS II: 24 GMFCS III: 10 |
Unilateral spastic: 26 Bilateral spastic: 41 Dyskinetic: 2 Ataxic: 1 |
||
Balemans et al.24,‡ | Secondary analysis RCT | CP: 46 | Boys: 26 Girls: 20 |
9.6 ± 1.7 | GMFCS I: 26 GMFCS II: 12 GMFCS III: 8 |
Unilateral spastic: 22 Bilateral spastic: 24 |
Balemans et al.25,‡ | Secondary analysis RCT | CP: 46 | Boys: 26 Girls: 20 |
9.6 ± 1.7 | GMFCS I: 26 GMFCS II: 12 GMFCS III: 8 |
Unilateral spastic: 22 Bilateral spastic: 24 |
Balemans et al.26 | Cross-sectional case-control study | TD: 20 | Boys: 8 Girls: 12 |
11.7 ± 3.4 | na | na |
CP: 37 | Boys: 18 Girls: 19 |
11.3 ± 3.1 13.9 ± 3.6 16.3 ± 4.9 |
GMFCS I: 13 GMFCS II: 17 GMFCS III: 7 |
Unilateral spastic: 6 Bilateral spastic: 31 |
||
Brehm et al.27,‡ | Clinimetric study (test-retest) | CP: 16 | Boys: 9 Girls: 7 |
10.5 ± 2.1 | GMFCS I: 3 GMFCS II: 11 GMFCS III: 2 |
Unilateral spastic: 2 Bilateral spastic: 14 |
Dahlbäck and Norlin28 | UCT | CP: 6 | NR | [9–15] | NR | Bilateral spastic: 6 |
Dallmeijer and Brehm29 | Cross-sectional case-control study | TD: 10 | Boys: 5 Girls: 5 |
9.8 ± 2.9 | na | na |
CP: 8 | Boys: 4 Girls: 4 |
9.9 ± 3.0 | GMFCS I: 7 GMFCS II: 1 |
Unilateral spastic: 3 Bilateral spastic: 5 |
||
Depiazzi et al.30 | Pilot RCT | CP control: 6 | Boys: 2 Girls: 4 |
14.7 ± 2.5 | GMFCS II: 6 | NR |
CP intervention: 6 | Boys: 3 Girls: 3 |
14.1 ± 1.6 | GMFCS II: 6 | NR | ||
Garcia et al.31 | Cross-sectional case-control study | TD: 40 | Boys: 21 Girls: 19 |
11.0 ± 3.6 | na | na |
CP: 40 | Boys: 21 Girls: 19 |
11.0 ± 3.3 | GMFCS levels I and II | Bilateral spastic: 40 | ||
Hoofwijk et al.32,‡ | Cross-sectional case-control study | TD: 9 | Boys: 7 Girls: 2 |
14.0 ± 2.4 | na | na |
CP: 9 | Boys: 7 Girls: 2 |
13.5 ± 2.7 | NR | Unilateral spastic: 1 Bilateral spastic: 8 |
||
Jung et al.33 | Preliminary case series study | TD: 2 | Boys: 1 Girls: 1 |
9.5 ± 3.5* | na | na |
CP: 4 | Boys: 3 Girls: 1 |
11 ± 3.4* | GMFCS I: 1 GMFCS II: 3 |
Unilateral spastic: 2 Bilateral spastic: 2 |
||
Kim et al.34,‡ | Baseline data RCT | CP: 40 | Boys: 21 Girls: 19 |
7.4 ± 1.6 | GMFCS I: 21 GMFCS II: 19 |
Unilateral spastic: 18 Bilateral spastic: 22 |
Klimek-Piskorz and Piskorz35 | Cross-sectional study | CP: 14 | NR | [16–17] | NR | Spastic: 14 |
Klimek-Piskorz et al.36 | Cross-sectional case-control study | TD: 10 | Boys: 10 Girls: |
16.1 ± 0.3 | na | na |
CP: 10 | Boys: 10 Girls: |
16.7 ± 0.5 | NR | Bilateral spastic: 10 | ||
Klimek-Piskorz37 | UCT | CP: 8 | Boys: 8 Girls: |
17.5 ± 0.3 | NR | Bilateral Spastic: 8 |
Lauglo et al.38 | UCT | CP: 20 | Boys: 11 Girls: 9 |
14 [13–16]# | GMFCS I: 8 GMFCS II: 4 GMFCS III: 3 GMFCS IV: 5 |
Unilateral spastic: 9 Bilateral spastic: 7 Dyskinetic: 3 Ataxic: 1 |
Lee et al.39 | Baseline data RCT | CP: 39 | Boys: 21 Girls: 18 |
7.44 ± 1.60 | GMFCS I: 21 GMFCS II: 18 |
Unilateral spastic: 19 Bilateral spastic: 20 |
Leunkeu et al.40 | Cross-sectional case-control study | TD: 10 | NR | 14 ± 0.6 | na | na |
CP: 9 | NR | 13 ± 1.9 | NR | Unilateral spastic: 4 Bilateral spastic: 5 |
||
Leunkeu et al.21 | Cross-sectional case-control study | TD: 8 | Boys: 8 Girls: |
14 ± 1 | na | na |
CP: 8 | Boys: 6 Girls: 2 |
14 ± 1 | GMFCS I: 4 GMFCS II: 4 |
Unilateral spastic: 4 Bilateral spastic: 4 |
||
Nsenga Leunkeu et al.44,‡ | CCT | CP control: 12 | Boys: 6 Girls: 6 |
14.2 ± 1.8 | GMFCS I: 8 GMFCS II: 4 |
Unilateral spastic: 10 Bilateral spastic: 2 |
CP intervention: 12 | Boys: 6 Girls: 6 |
14.2 ± 1.9 | GMFCS I: 8 GMFCS II: 4 |
Unilateral spastic: 10 Bilateral spastic: 2 |
||
Nsenga et al.45,‡ | CCT | TD: 10 | Boys: 6 Girls: 4 |
14.1 ± 2.1 | na | na |
CP control: 10 | Boys: 6 Girls: 4 |
14.2 ± 1.8 | GMFCS I: 7 GMFCS II: 3 |
Unilateral spastic: 8 Bilateral spastic: 2 |
||
CP intervention: 10 | Boys: 6 Girls: 4 |
14.2 ± 1.9 | GMFCS I: 7 GMFCS II: 3 |
Unilateral spastic: 8 Bilateral spastic: 2 |
||
Lundberg41 | Cross-sectional case-control study | TD: 9 | Boys: 6 Girls: 3 |
11.7 ± 0.5 11.7 ± 0.6 |
na | na |
CP: 9 | Boys: 5 Girls: 4 |
11.4 ± 0.5 11.8 ± 0.5 |
NR | Bilateral spastic: 9 | ||
Lundberg42 | Longitudinal study (approx. 6 years) | TD: 12 | Boys: 7 Girls: 5 |
12.3 ± 1.2 | na | na |
CP: 26 | Boys: 19 Girls: 7 |
11.5 ± 1.9 12.0 ± 0.3 11.2 ± 2.2 |
NR | Unilateral spastic: 3 Bilateral spastic: 19 Dyskinetic: 4 |
||
Maltais et al.43 | Cross-sectional study | CP: 11 | Boys: 7 Girls: 4 |
13 ± 1.4 | GMFCS levels I and II | Unilateral spastic: 4 Bilateral spastic: 7 |
Massin and Allington22 | UCT | CP: 15 | Boys: 9 Girls: 6 |
6.5 ± 2.3* | NR | Unilateral spastic: 9 Bilateral spastic: 6 |
Park et al.46,‡ | Pilot RCT | CP control: 13 | Boys: 8 Girls: 5 |
7.5 ± 1.6 | GMFCS I: 7 GMFCS II: 6 |
NR |
CP intervention: 13 | Boys: 6 Girls: 7 |
8.2 ± 1.9 | GMFCS I: 7 GMFCS II: 6 |
NR | ||
Piskorz and Klimek-Piskorz47 | Clinimetric study (compares 2 test modalities) | CP: 15 | Boys: 15 Girls: |
[16–17] | NR | Bilateral spastic: 15 |
Sansare et al.48 | RCT | CP control: 11 | Boys: 9 Girls: 2 |
13.7 ± 2.9 | GMFCS II: 4 GMFCS III: 4 GMFCS IV: 3 |
Spastic: 11 |
CP intervention I: 14 | Boys: 13 Girls: 1 |
14.5 ± 2.4 | GMFCS II: 6 GMFCS III: 3 GMFCS IV: 5 |
Spastic: 14 | ||
CP intervention II: 11 | Boys: 8 Girls: 3 |
12.7 ± 2.1 | GMFCS II: 2 GMFCS III: 4 GMFCS IV: 5 |
Spastic: 11 | ||
Suk and Kwon49,‡ | RCT | CP control: 23 | Boys: 12 Girls: 11 |
7.2 ± 1.5 | GMFCS I: 11 GMFCS II: 10 GMFCS III: 2 |
Unilateral spastic: 9 Bilateral spastic: 14 |
CP intervention: 23 | Boys: 12 Girls: 11 |
7.7 ± 1.6 | GMFCS I: 10 GMFCS II: 9 GMFCS III: 4 |
Unilateral spastic: 10 Bilateral spastic: 13 |
||
Unnithan et al.50,‡ | Cross-sectional case-control study | TD: 9 | Boys: 7 Girls: 2 |
13.6 ± 2.1 | na | na |
CP: 9 | Boys: 7 Girls: 2 |
12.7 ± 2.8 | NR | Unilateral spastic: 1 Bilateral spastic: 8 |
||
Unnithan et al.51 | CCT | CP control: 6 | Boys: 2 Girls: 4 |
15.7 ± 1.2 | GMFCS levels II and III | Bilateral spastic: 6 |
CP intervention: 7 | Boys: 2 Girls: 5 |
15.9 ± 1.5 | GMFCS levels II and III | Bilateral spastic: 7 | ||
Van Wely et al.52,‡ | RCT | CP control: 24 | Boys: 16 Girls: 8 |
10.0 ± 1.8 | GMFCS I: 13 GMFCS II: 6 GMFCS III: 5 |
Unilateral spastic: 11 Bilateral spastic: 13 |
CP intervention: 25 | Boys: 12 Girls: 13 |
9.5 ± 1.5 | GMFCS I: 15 GMFCS II: 6 GMFCS III: 4 |
Unilateral spastic: 12 Bilateral spastic: 13 |
||
Verschuren et al.53,‡ | Clinimetric study (compares 2 test modalities) | CP: 25 | Boys: 15 Girls: 10 |
11.5 ± 2.8 12.5 ± 3.0 |
GMFCS I: 14 GMFCS II: 11 |
NR |
Verschuren and Takken20,‡ | Cross-sectional study | CP: 24 | Boys: 16 Girls: 8 |
11.2 ± 2.8 12.5 ± 3.0 |
GMFCS I: 13 GMFCS II: 11 |
Unilateral spastic: 12 Bilateral spastic: 12 |
Verschuren et al.54 | Clinimetric study (compares 2 test modalities) | CP: 23 | Boys: 18 Girls: 5 |
13.3 ± 3.6 | GMFCS III: 3 GMFCS IV: 20 |
Spastic: 23 |
Zwinkels et al.55,‡ 2004-matched sample |
Comparing 2004 and 2014 samples | CP: 15 | Boys: 10 Girls: 5 |
11.9 ± 2.8 13.4 ± 2.0 |
GMFCS I: 8 GMFCS II: 7 |
Spastic: 15 |
2014-matched sample | CP: 15 | Boys: 10 Girls: 5 |
12.0 ± 2.7 13.5 ± 2.9 |
GMFCS I: 8 GMFCS II: 7 |
Spastic: 15 | |
Total# |
TD: 180 CP: 843 |
Boys: 586 Girls: 398 Missing:39 |
CP: 12.62 (SE 0.54)⁎⁎ TD: 12.43 (SE 0.72)⁎⁎ |
GMFCS I: 302 GMFCS II: 242 GMFCS III: 67 GMFCS IV: 38 GMFCS V: 0 Missing: 194 |
Unilateral spastic: 245 Bilateral spastic: 421 Spastic: 103 Dyskinetic: 9 Ataxic: 2 Missing: 63 |
Study shows overlap in participants with other study/studies.
Data were available per participant, and therefore the mean and standard deviation were manually calculated.
Data reported as median (IQR).
Pooled average of age of unique children
Abbreviations: CCT, controlled clinical trial; CP, cerebral palsy; n, number; na, not applicable; NR, not reported; RCT, Randomized Controlled Trial; SD, standard deviation; SE, standard error; TD, typically developing; UCT, uncontrolled clinical trial.