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. 2024 Nov 29;52(11):03000605241300067. doi: 10.1177/03000605241300067

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© The Author(s) 2024

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — Biglycan (BGN) mRNA levels were upregulated in colon cancer and correlated with prognosis. BGN mRNA levels in colon cancer tissues (T) and normal tissues (N) were analysed using data from The Cancer Genome Atlas (TCGA; tumour, n = 275; normal, n = 349) (a) (central black line is the mean; the extremities of the box are the 25th and 75th percentiles; error bars represent minimum and maximum outliers); and the Gene Expression Omnibus databases (b & c; GSE20916: tumour, n = 66; normal, n = 79; GSE39582: tumour, n = 19; normal, n = 566). (d) Levels of BGN mRNA in 47 tumour tissues and 47 adjacent normal tissues was examined using real-time polymerase chain reaction. (e & f) Overall survival and disease-free survival analyses using TCGA data. For b, c and d, the data are presented as mean ± SD; *P < 0.05, ****P < 0.0001. The colour version of this figure is available at: http://imr.sagepub.com. COAD, Colon Adenocarcinoma Collection.