Table 4.
Active and ongoing trials for management of cancer treatment-related xerostomia
| Country | Study design | Study population | Intervention(s) | Source ID (clinicaltrials.gov) |
|---|---|---|---|---|
| USA | Randomized, multicenter, double-blinded, controlled trial | Adults with radiation-induced late xerostomia |
AAV2-hAQP1 Gene therapy |
NCT05926765 |
| USA | Dose-escalation phase I trial | Post-radiation adults with head and neck cancer |
AAV2-hAQP1 Gene therapy |
NCT02446249 |
| Denmark | Randomized, single-center, double-blinded, controlled trial (phase II) | Post-radiation adults with head and neck cancer | Mesenchymal stem cells | NCT04776538 |
| Denmark | Non-randomized phase I | Post-radiation adults with oropharynx cancer | Mesenchymal stem cells | NCT03874572 |
| USA | Dose-escalation phase I trial | Adult head and neck cancer patients | Bone marrow cell transplantation into the salivary glands | NCT05820711 |
| Brazil | Randomized, multicenter, single-blinded controlled clinical trial | Post-radiation adults with head and neck cancer | Photobiomodulation (Intraoral and extraoral) | NCT05242991 |
| Brazil | Randomized, multicenter, single-blinded clinical trial | Adult patients undergoing hematopoietic cell transplantation | Photobiomodulation (Intraoral and extraoral) | NCT05759975 |
| Spain | Randomized, single-center, double-blinded controlled trial | Adult head and neck cancer patients | Photobiomodulation (Intraoral and extraoral—along with M-health tool) | NCT05106608 |
| USA | Single-arm prospective study | Post-radiation adults with head and neck cancer | Non-invasive acupuncture-like transcutaneous electrical nerve stimulation (ALTENS) | NCT04805528 |
| USA and China | Randomized, multicenter, controlled trial | Adults with head and neck cancer, scheduled to undergo IMRT | Acupuncture | NCT01266044 |
| France | Randomized, multicenter, single-blinded clinical trial | Adult head and neck cancer patients | Auriculotherapy | NCT04222478 |
| Denmark | Single-arm pilot trial | Post-radiation adults with head and neck cancer | Craniosacral therapy | NCT05882890 |
| France | Randomized, single-center, controlled trial | Post-radiation adults with head and neck cancer | Corticosteroids | NCT04584164 |
| Cyprus | Randomized, multicenter, double-blinded controlled trial | Adult head and neck cancer patients undergoing radiotherapy | Thyme and honey spray | NCT04880148 |
| China | Randomized, multicenter, non-inferiority, controlled trial | Adult patients with nasopharyngeal carcinoma | Intensity-modulated radiation therapy (IMRT) | NCT06282497 |
| Switzerland | Single-arm trial | Adults with head and neck cancer | Adaptive radiation therapy | NCT03972072 |
| USA | Randomized, single-center, controlled trial | Adults with squamous cell carcinoma of the head and neck | IMRT (margin-based vs. robust photon radiation therapy planning) | NCT03552965 |
AAV2-hAQP1 Adeno-associated viral vector encoding human Aquaporin-1, ALTENS Acupuncture-like transcutaneous electrical nerve stimulation, IMRT Intensity-modulated radiation therapy