Table 4.

The corresponding p values of significant SNPs of M-Phen in the analysis of COPDGene using different imputation methods

Chr:bp$_{}^1$	SNP$_{}^2$	Unimputed	PHENIX	PIM	C-MSE	C-(0–1)	C-QL
4:145431497	rs1512282	$1.03E-9$	$\mathbf{7.33}\mathbf{E}-\mathbf{12}$	$9.15E-12$	$1.11E-11$	$1.12E-11$	$1.11E-11$
4:145434744	rs1032297	$7.69E-14$	$7.44E-15$	$7.22E-15$	$\mathbf{2.55}\mathbf{E}-\mathbf{15}$	$2.66E-15$	$\mathbf{2.55}\mathbf{E}-\mathbf{15}$
4:145474473	rs1489759	$1.22E-16$	$4.44E-16$	$\mathbf{1.11}\mathbf{E}-\mathbf{16}$	$\mathbf{1.11}\mathbf{E}-\mathbf{16}$	$\mathbf{1.11}\mathbf{E}-\mathbf{16}$	$\mathbf{1.11}\mathbf{E}-\mathbf{16}$
4:145485738	rs1980057	$8.14E-17$	$1.11E-16$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$
4:145485915	rs7655625	$9.13E-17$	$1.11E-16$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$
15:78882925	rs16969968	$7.84E-12$	$3.26E-14$	$2.20E-14$	$1.10E-14$	$\mathbf{1.08}\mathbf{E}-\mathbf{14}$	$1.10E-14$
15:78894339	rs1051730	$8.16E-12$	$3.10E-14$	$2.02E-14$	$9.44E-15$	$\mathbf{9.33}\mathbf{E}-\mathbf{15}$	$9.44E-15$
15:78898723	rs12914385	$1.48E-12$	$1.59E-14$	$4.55E-15$	$2.11E-15$	$\mathbf{2.00}\mathbf{E}-\mathbf{15}$	$2.11E-15$
15:78911181	rs8040868	$2.59E-12$	$6.99E-15$	$2.89E-15$	$2.11E-15$	$\mathbf{2.00}\mathbf{E}-\mathbf{15}$	$2.11E-15$
15:78878541	rs951266	$1.02E-11$	$6.71E-14$	$5.87E-14$	$2.24E-14$	$\mathbf{2.20}\mathbf{E}-\mathbf{14}$	$2.24E-14$
15:78806023	rs8034191	$7.74E-11$	$4.17E-13$	$\mathbf{7.84}\mathbf{E}-\mathbf{14}$	$9.41E-14$	$9.26E-14$	$9.41E-14$
15:78851615	rs2036527	$1.77E-10$	$2.69E-13$	$6.29E-14$	$6.04E-14$	$\mathbf{5.94}\mathbf{E}-\mathbf{14}$	$6.04E-14$
15:78826180	rs931794	$9.09E-11$	$2.99E-13$	$\mathbf{7.59}\mathbf{E}-\mathbf{14}$	$9.14E-14$	$9.00E-14$	$9.14E-14$
15:78740964	rs2568494	$4.23E-8$	$8.91E-11$	$1.01E-10$	$7.35E-11$	$\mathbf{7.21}\mathbf{E}-\mathbf{11}$	$7.36E-11$

$_{}^1$Chr:bp denotes chromosome and base pair position

$_{}^2$SNP denotes Single Nucleotide Polymorphism

Bold values indicate the smallest p value for the genetic association tests using imputed and unimputed data for each SNP