Table 6.

The corresponding p values of significant SNPs of Tippet in the analysis of COPDGene for different imputation methods

Chr:bp$_{}^1$	SNP$_{}^2$	Unimputed	PHENIX	PIM	C-MSE	C-(0–1)	C-QL
4:145431497	rs1512282	$8.00\times {10}^{-9}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$
4:145434744	rs1032297	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$
4:145474473	rs1489759	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$
4:145485738	rs1980057	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$
4:145485915	rs7655625	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$
15:78882925	rs16969968	$4.90\times {10}^{-8}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$
15:78894339	rs1051730	$4.20\times {10}^{-8}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$
15:78898723	rs12914385	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$
15:78911181	rs8040868	$5.00\times {10}^{-9}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$
15:78878541	rs951266	$8.10\times {10}^{-8}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$
15:78806023	rs8034191	$1.70\times {10}^{-7}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$
15:78851615	rs2036527	$2.41\times {10}^{-7}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$
15:78826180	rs931794	$1.94\times {10}^{-7}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$
15:78740964	rs2568494	$3.42\times {10}^{-5}$	$3.00\times {10}^{-6}$	$2.00\times {10}^{-6}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$	$<\mathbf{1.00}\mathbf{E}-\mathbf{16}$

$_{}^1$Chr:bp denotes chromosome and base pair position

$_{}^2$SNP denotes Single Nucleotide Polymorphism

Bold values indicate the smallest p value for the genetic association tests using imputed and unimputed data for each SNP