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. 2024 Nov 30;16:259. doi: 10.1186/s13195-024-01623-4

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Overview of the differentially expressed genes and DNA (hydroxy)methylation levels within the TRP metabolic pathway and NAD pathway. Within the TRP metabolic pathway, a total of 12 genes exhibited significant differential gene expression, while 20 genes were differentially expressed within the NAD pathway. Genes exhibiting up-regulation in expression are highlighted with red box, whereas those with down-regulation are indicated by blue box. Genes with altered DNA (hydroxy)methylation levels are denoted by circular markers, with distinct colors representing specific modifications: 5mC (green), 5hmC (purple), and 5uC (orange)