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. 2024 Nov 30;16:259. doi: 10.1186/s13195-024-01623-4

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Gene regulatory network (GRN) of TRP and NAD pathway. A TRP GRN representing the control phenotype and containing 22 nodes and 30 interactions, (B) TRP GRN representing Alzheimer’s disease (AD) phenotype and containing 22 nodes and 25 interactions, (C) NAD GRN representing the control phenotype and containing 13 nodes and 21 interactions, (D) NAD GRN representing Alzheimer’s disease (AD) phenotype and containing 14 nodes and 24 interactions. Green line indicates gene activation while red line indicates gene inhibition